Eliciting 'indigestion' in mosquitoes: evaluation of a molecular target for the development of new adulticides that disrupt blood digestion

Principal Investigator: Peter Piermarini 

Mosquitoes are rapidly developing resistance to conventional insecticides that target the central nervous system. This research aims to disrupt the function of the protein hypothesized to be key in the role of absorption of blood plasma by the adult female mosquito. It seeks to evaluate an inward-rectifying potassium (Kir) channel (Kir2A) as a new potential molecular target for development of adult insecticides. This would likely lead to decreased reproductive value and/or death. The research could validate a new molecular target for mosquito control and provide insights into the physiology of the mosquito midgut.